Antitumor effects of a podophyllotoxin derivative, VP 16-213.
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چکیده
منابع مشابه
VP 16-213 in acute myelogenous leukaemia.
The use of the epipodophyllotoxin VP 16-213 is described in twenty patients with acute myelogenous leukaemia resistant to other chemotherapy. The drug was usually given in 5-day courses of 50 mg/M2 daily and occasionally in 24-hr infusions of 250 mg/M2, on the basis of its phase-activity. Complete remission was achieved in only two patients: in one of these, remission was maintained with VP 16-...
متن کاملAnalysis of the Inhibitory Effects of VP-16-213 (Etoposide) and Podophyllotoxin on Thymidine Transport and Metabolism in Ehrlich Ascites Tumor Cells in Vitro1
These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]thymidine is characterized by a rapid initial velocity that approx imates membrane transport followed by a slower rate of uptake that parallels the accumulation of phosphorylated derivatives of thymidine, pri...
متن کاملAnalysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.
These studies explore the effects of an epipodophyllotoxin on the membrane transport and metabolism of thymidine in Ehrlich ascites tumor cells. Uptake of 3H after exposure of cells to [3H]-thymidine is characterized by a rapid initial velocity that approximates membrane transport followed by a slower rate of uptake that parallels the accumulation of phosphorylated derivatives of thymidine, pri...
متن کاملOral VP-16-213 in advanced bronchogenic carcinoma and toxic effects when combined with methotrexate.
Forty-six patients with histologically confirmed lung cancer received treatment with the cytotoxic drug VP-16-213 in a dose of 100 mg twice daily, given orally for five days. The overall objective response rate was 11 out of 46 (24%) or 11 of the 33 (33%) who survived to receive two cycles. The drug was effective in all histological types. Only one patient developed leucopenia. This demonstrati...
متن کاملEffect of an epipodophyllotoxin derivative (VP 16-213) on macromolecular synthesis and mitosis in mastocytoma cells in vitro.
The influence of the semisynthetic epipodophyllotoxin derivative VP 16-213 on different cellular and biochemical parameters was determined with the use of suspension cultures of a murine mastocytoma. Cells were exponentially dividing and not synchronized. Treatment with VP 16-213 (l ¿ig/ml) reduced the mitotic index by more than 75% within 1.5 hr and completely prevented cell multiplication up...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1986
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.87.53